Laboratory of Functional and Evolutionary Genomics

Team

Research area

We conduct research in the field of functional, comparative and evolutionary genomics. We are focused on the evolution and function of retroposed genes and the regulation of the expression of genes that form sense/antisense pairs. In our daily work, we use both bionformatics and laboratory methods.

Research topics

• Evolution and functions of retrogenes;
• Retrogenes and lncRNA in cancerogenesis;
• lncRNA epitranscriptomics;
• Alternative promoters and expression regulation of overlapping genes;
• Third-generation sequencing (long-read sequencing) in human microbiom analysis;

Grants

2023

• Retrogenes as important players in cancer regulatory pathways
  • Principal investigator: Klaudia Staszak, MSc
  • Website: project description (National Science Centre)

2018

• Expression regulation of protein-coding genes overlapping at their 5′ ends
  • Principal investigator: Professor Izabela Makałowska
  • Website: project description (National Science Centre)

• The roles of lncRNAs in alternative splicing regulation and modulation of chromatin structure
  • Principal investigator: Elżbieta Wanowska, PhD
  • Website: project description (National Science Centre)

• The role of retrogenes in splicing regulation
  • Principal investigator: Magdalena Kubiak, PhD
  • Website: project description (National Science Centre)

2014

• From From junk to treasure – functional evolution of retrogenes
  • Principal investigator: Professor Izabela Makałowska
  • Website: project description (National Science Centre)

2011

• New methods of identification and analysis of functional retrogenes in animal genomes
  • Principal investigatior: Joanna Ciomborowska, PhD
  • Website: project description (National Science Centre)

Publications